Skin disorder:
The exact cause of the Vitiligo is an enigma, but several hypotheses about its pathogenesis are advanced.
The autoimmune hypothesis proposes an autoimmune attack against melanocytes. Although anti-melanocyte autoantibodies have been demonstrated in vitiligo, recent research casts doubt on their pathogenic role and instead supports the involvement of cell-mediated autoimmune response in the pathobiology of this disorder, which is characterized by increase of suppressor T-cells and decrease of the helper/suppressor ratio in association with the presence of type-1 cytokine secreting cytotoxic T cells in the vicinity of disappearing melanocytes.
The neural hypothesis proposes that increased release of norepinephrine, a melanocytotoxin, from the autonomic nerve endings in the microenvironment of melanocytes injures these cells. Moreover, norepinephrine induces the catecholamine degrading enzyme monoamine oxidase (MAO), which favors the formation of toxic levels of hydrogen peroxide in the vicinity of melanocytes.
Another theory suggests that abnormal permeability of melanosome membrane, which normally prevents the diffusion of toxic melanin precursors into the cytoplasm, may cause melanocyte damage.
The drug formula C15H12N2O2 from Glycolic group with two phenyls has been shown to significantly suppress mitogen-induced activation of lymphocytes and cytotoxic T lymphocyte activity and to polarize the immune response toward the type-2 pathway. It also significantly decreases suppressor T cells and increases the helper/suppressor ratio.
At high concentrations, the drug inhibits the release of norepinephrine and the activity of MAO. Moreover, this drug is suggested to interact with membrane lipids, which may promote stabilization of the membranes.
In the Glycolil group the hydantoin moiety of phenytoin exerts a direct stimulatory action on melanocytes; facial hyperpigmentation is a recognized side effect of orally administered phenytoin.
Altogether, the above evidence suggests that this compound formula could be therapeutically effective against vitiligo. As phenytoin stimulates collagen production and inhibits its breakdown, its concomitant use with topical steroids could prevent steroid-induced skin atrophy while potentiating the anti-vitiligo effect of these agents.
Working Condition: Temp: 5~40°C, RH: ≤85%
Atmospheric pressure: 700hPa~1060hPa
Effective Distance: Apply on the skin
Treatment Area recommended: No more than 5cm2±2%
Conteiner Dimensions (L x W x H): 2 x 2 x 2 in
Weight: about 8 ounce
Presentation: 15g 60g and 90g
Indication: Helps to have Psoriasis and Vitiligo remissions, Eczema.
Distributed: World wide
Contraindications and warning: Do not use during pregnancy or Breastfeeding. Do not recommended in people with HLA-B allele, HLA-B*1502
Delivery: Free delivery 3 to 5 days by USPS Small Box/Envelope or Fedex 2nd day (optional, fee applies)
International delivery available (Fee applies)
